Sildenafil Ingredients

Sildenafil has become an extremely popular drug due to its efficacy in treating erectile dysfunction in men. 

The predominant active component in Sildenafil is Sildenafil Citrate. Sildenafil Citrate works by acting as a blocker of cGMP-specific phosphodiesterase type 5 (PDE5). This interaction allows another enzyme, cyclic guanosine monophosphate (cGMP), to flourish in the pelvic area, specifically in the penis. By allowing the cGMP to flourish, Sildenafil thus makes it possible for the blood vessels in the pelvic area to expand, enabling a natural erection after consumption of the pill.

Names and Ingredients

The full scientific name of Sildenafil Citrate is 5-{2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one. The tablets that you can get are often either white or off-white, engraved with a “25” on one side of the tablet, typically diamond in shape. Depending on the manufacturer and the tablet, the medication may have 25 milligrams, 50 milligrams, or 100 milligrams of Sildenafil Citrate.

However, Sildenafil Citrate is not the only ingredient that is included in the manufacturing of Sildenafil. There are a number of other, inactive ingredients as well. While these ingredients are not necessarily vital to how the pill works, it is still important to include them. This is because you may be allergic or have a reaction to any number of these ingredients. Alternatively, a medication that you are currently taking may react adversely with some of these inactive ingredients.

With that in mind, the following is a list of the inactive ingredients present within the core of the Sildenafil tablet: calcium hydrogen phosphate (anhydrous), microcrystalline cellulose, magnesium stearate, and croscarmellose sodium.

However, there are still other inactive ingredients present within the film coating that covers the tablet. Here is a list of the ingredients in the film coat: hypromellose, triacetin, lactose, titanium dioxide (E171).

Side Effects


As with any medication, some of the ingredients present within the pill may produce some adverse side effects. Not all of the side effects are going to present themselves to you, but if they should, you should contact your doctor as soon as you can. Even some of the more benign side effects could be a warning of something more severe, such as an allergic reaction.

However, generally speaking, side effects that are associated with Sildenafil are very mild, and they typically do not last beyond the effects of the medication. That duration is usually between 4 to 6 hours. Should any side effects that you experience last beyond that time period, you should contact your doctor.

With that in mind, please read over the following lists of potential side effects that may occur from taking Sildenafil.

  • Allergic reaction. This can present itself suddenly, without much warning. Although it is not a common side effect, it can still be very serious. Common signs of an allergic reaction include issues with breathing or dizziness, sudden wheezing, and swelling of the eyelids, lips, face, or throat.
  • Chest Pains. Although this is another uncommon occurrence, it is still potentially dangerous to you. Should this side effect come up in the middle of or after sexual intercourse, you should stop immediately. Attempt to move yourself into a half-sitting position and do your best to relax. Tensing can only exacerbate the issue. Do not take any kind of nitrate to try to relieve the symptoms, as this could result in a drastic loss of blood pressure.

Following is a listing of the rarer side effects. If you discover that you have any one of these, contact your doctor as soon as possible.

  • Painful or prolonged erections. Despite this side effect being quite rare, it could be a sign of something worse. Should your erection last for more than 4 hours, you should contact your doctor immediately.
  • A sudden loss or decrease of vision.
  • Severe skin reactions. Symptoms to look for include severe peeling and swelling of the skin, blisters in or around the mouth, genitals and eyes, or a fever.
  • Fits or seizures.

Following is a list of the more common side effects. These should not last for more than the duration of the medication. As mentioned previously, the effects of Sildenafil typically last for between 4 and 6 hours.

  • Nausea
  • Hot flashes (a common symptom of this is a sudden feeling of heat in the upper body)
  • Indigestion
  • A colour-tinged or blurred vision
  • Visual disturbances
  • Stuffy nose
  • Dizziness

Again, please contact your doctor if any of these last for more than 6 hours.

About Asim FarooqDr Asim Farooq was born in Surrey and raised in Sussex where he attended boarding school at Brighton College. After this, he went on to study medicine at Kings College, London. After graduating, he worked in various hospitals gaining experience in a nunmber of clinical areas until he joined the GP training scheme and worked as an SHO in Accident & Emergency, Obstetrics & Gynaecology, Paediatrics and Care for the Elderly.

His interest in diabetes management has led him to co-author a book and attend various advanced level courses which permits him to initiate injectable therapies. He has also assisted in setting up and managing an excellent diabetes management service alongside two specialist nurses in Croydon.
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